Ultrasmall Fe3O4 and Gd2O3 hybrid nanoparticles for T1-weighted MR imaging of cancer

Abstract Gadolinium-based contrast agents (GdCAs) have been the most frequently used T 1 -weighted magnetic resonance imaging (MRI) for decades. However, they serious disadvantages such as low longitudinal relaxivity value ( r ) and high dose associated-nephrotoxicity that restrict their wide applications. These emphasize need an ideal stable biocompatible CA with enhancement performance. Here, we propose a wet-chemical synthesis technique to form nanocomposite consisting of ultrasmall iron oxide nanoparticles (US-IO) Gd 2 O 3 hybrid stabilized dextran (FG-HNPs) MR imaging. Relaxometry study showed FG-HNPs (42.28 mM −1 S ratio / : 1.416) at 3.0T. In vivo MRI factor (ΔSNR) (257.025 ± 17.4%) was found be 1.99-fold higher than US-IO (129.102 15%) 3.35-fold Dotarem (76.71 14.2%) routinely CA. The cytotoxicity assay histological examination confirmed biocompatibility FG-HNPs. biodistribution study, transmission electron microscopy (TEM) Prussian blue (PB) staining tumor tissue proved effective localization Therefore, can suggested promising tumors by virtue remarkable relaxivities biocompatibility.